Champions Manchester City face West Ham away on the opening weekend of a 2022-23 Premier League campaign that will include a mid-season break for the World Cup in Qatar.
There will be no top-flight games after the weekend of 12-13 November until 26 December because of the World Cup.
The first fixture takes place on Friday, 5 August when Crystal Palace host Arsenal.
Liverpool play at promoted Fulham, with Nottingham Forest at Newcastle.
The World Cup, which will feature both England and Wales, starts on 21 November. The final is on 18 December, eight days before the Premier League season resumes.
First round of fixtures in full
Crystal Palace v Arsenal
Bournemouth v Aston Villa
Everton v Chelsea
Fulham v Liverpool
Leeds United v Wolverhampton
Leicester City v Brentford
Newcastle United v Nottingham Forest
Tottenham Hotspur v Southampton
Manchester United v Brighton
West Ham United v Manchester City